| 聚酯型Gd(Ⅲ)配合物的合成与表征 |
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| 引用本文： | 柏正武,卓仁禧.聚酯型Gd(Ⅲ)配合物的合成与表征[J].高分子学报,1998,26(2):191-195. |
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| 作者姓名： | 柏正武 卓仁禧 |
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| 作者单位： | 武汉大学化学系,国家教委生物医用高分子材料开放实验室,武汉,430072 |
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| 摘 要： | 将二乙三胺五乙酸双酐与五种分子量不同的聚乙二醇共缩聚，制得聚酯型大分子配体，配体与ＧｄＣｌ３·６Ｈ２Ｏ反应，生成相应的配合物，并测试了配合物的弛豫速率．结果表明这些配合物比现用于临床的磁共振成像造影剂Ｇｄ（ＤＴＰＡ）具有更高的弛豫速率．
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| 关 键 词： | 大分子MRI造影剂，钆配合物，弛豫速率 |
SYNTHESIS AND CHARACTERIZATION OF POLYESTER Gd(Ⅲ) COMPLEXES |
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| BAI Zhengwu,ZHUO Renxi.SYNTHESIS AND CHARACTERIZATION OF POLYESTER Gd(Ⅲ) COMPLEXES[J].Acta Polymerica Sinica,1998,26(2):191-195. |
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| Authors: | BAI Zhengwu ZHUO Renxi |
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| Abstract: | Five new polyester ligands were prepared by the condensation polymerization of diethylenetriaminepentaacetic dianhydride with PEG of various molecular weight (Mn).By the reaction of these macromolecular ligands with GdCl 3·6H 2O,the corresponding metal complexes were obtained.Preliminary results showed that the relaxivity of these macromolecular gadolinium complexes were higher than that of Gd(DTPA) which is widely used in clinical diagnosis. |
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| Keywords: | Macromolecular MRI contrast agent Gadolinium complex Relaxivity |
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