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Voltammetric determination of 5-hydroxydole-3-acetic acid in human gastric juice |
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| Authors: | Liu Y Jiang Y Song W Lu N Zou M Xu H Yu Z |
| Institution: | a Department of Chemistry, Jilin University, Changchun 130023, People's Republic of China b The First Clinic Hospital Attached to Bethun Medical College, Changchun 130023, People's Republic of China |
| Abstract: | A method for the determination of the major serotonin metabolite — 5-hydroxyindole-3-acetic acid (5-HIAA) in human gastric juice by cyclic voltammetry was described. The measurement conditions were investigated. The potential window was chosen from +0.1 to +0.9 V, the supporting electrolyte was 0.025 M PBS solution (pH 2.0). The method allowed determination in the concentration range from 2.0 ×10?7 to 2.0 ×10 ?5 M and a detection limit of 80 nM. When samples of gastric juice were analyzed with the method, we obtained the mean content of 5-HIAA in the gastric juice. Meanwhile, interference from other ions and substances were examined. The experimental results indicate that the method for the determination of gastric juice samples is successful. |
| Keywords: | 5-HIAA Cyclic voltammetry Human gastric juice |
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