4-Hydroxy-2-quinolones 123. Amidation of 2-bromomethyl-5-oxo-1,2-dihydro-5H-oxazolo[3,2-a]-quinoline-4-carboxylic acid |
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| Authors: | I. V. Ukrainets N. L. Bereznyakova A. V. Turov S. V. Shishkina |
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| Affiliation: | (1) National University of Pharmacy, Kharkiv, 61002, Ukraine;(2) Taras Shevchenko National University, Kiev, 01033, Ukraine;(3) STC Institute for Single Crystals, National Academy of Sciences, Kharkiv, 61001, Ukraine |
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| Abstract: | The reaction of 2-bromomethyl-5-oxo-1,2-dihydro-5H-oxazolo[3,2-a]quinoline-4-carboxylic acid with thionyl chloride is accompanied by a transformation of the oxazoloquinolone ring to give 4-chloro-1-(2,3-dichloropropyl)-2-oxo-1,2-dihydroquinoline-3-carboxylic acid chloride. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1034–1042, July, 2007. |
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| Keywords: | oxazolo[3,2-a]quinoline 4-chloro-2-quinolinone amidation ring closing X-ray analysis |
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