Febantel: looking for new polymorphs |
| |
Authors: | Bruni Giovanna Pardi Francesca Capsoni Doretta Berbenni Vittorio Bini Marcella Valle Giovanni Milanese Chiara Girella Alessandro Marini Amedeo |
| |
Institution: | 1.C.S.G.I. - Department of Chemistry, Physical-Chemistry Section, University of Pavia, Viale Taramelli 16, 27100, Pavia, Italy ;2.Teknofarma S.p.A, Strada Comunale da Bertolla all’Abbadia di Stura 14, 10156, Turin, Italy ; |
| |
Abstract: | The aim of this work was to search for new polymorphic forms of febantel, an anthelminthic drug of great present interest for the veterinary industry. Solvent-based recrystallization, thermal and mechanical treatments and spray drying were chosen to discover new solid forms. The solids obtained were physicochemically characterized by thermal techniques (DSC and TG), FTIR spectroscopy, laboratory and synchrotron X-ray powder diffraction and scanning electron microscopy. Our work leads to obtain a new solid form never described in the literature. In particular, the new polymorph was obtained by the anti-solvent method and the crystallization from isopropanol. The experimental conditions of crystallization favorable to the formation of the highest amount of the new solid phase were selected. The new phase shows a thermal, spectroscopic and diffractometric behavior unique. Furthermore, the preliminary structure investigation suggests two possible crystal systems: an orthorhombic or a monoclinic one, with really comparable lattice parameters and cell volume. Measurements put into evidence that the new phase is a metastable polymorph that is in monotropic relationship with the stable and known form. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|