| 多环芳烃暴露的生物标志物——尿中羟基多环芳烃 |
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| 引用本文： | 牛红云,蔡亚岐,魏复盛,牟世芬,江桂斌. 多环芳烃暴露的生物标志物——尿中羟基多环芳烃[J]. 化学进展, 2006, 18(10): 1381-1390 |
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| 作者姓名： | 牛红云 蔡亚岐 魏复盛 牟世芬 江桂斌 |
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| 作者单位： | 中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京,100085;中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京,100085;中国环境检测总站,北京,100029 |
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| 基金项目： | 国家重点基础研究发展计划(973计划);国家自然科学基金;中国科学院方向性项目 |
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| 摘 要： | 多环芳烃(PAHs) 是典型的持久性有机污染物,在职业高PAHs 暴露环境下,容易诱发肺癌、皮肤癌等癌症。对PAHs 的暴露评价可为流行病学研究和污染物风险评价等提供有效的数据。由于暴露途径的复杂化,采用尿样中PAHs 的代谢产物———羟基多环芳烃作为标志物来综合评价人体对PAHs 的内暴露情况已经成为研究的热点。本文系统介绍了多环芳烃的吸收、代谢、尿中PAHs 代谢产物的主要存在形式、主要的生物标志物以及它们的主要影响因素。
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| 关 键 词： | 多环芳烃 羟基多环芳烃 生物标志物 尿样 |
| 文章编号： | 1005-281X（2006）10-1381-10 |
| 收稿时间： | 2005-11-01 |
| 修稿时间： | 2006-02-01 |
Hydroxyl Polycyclic Aromatic Hydrocarbons in Human Urine as Biomarkers of Exposure to PAHs |
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| Niu Hongyun,Cai Yaqi,Wei Fusheng,Mou Shifen,Jiang Guibin. Hydroxyl Polycyclic Aromatic Hydrocarbons in Human Urine as Biomarkers of Exposure to PAHs[J]. Progress in Chemistry, 2006, 18(10): 1381-1390 |
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| Authors: | Niu Hongyun Cai Yaqi Wei Fusheng Mou Shifen Jiang Guibin |
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| Affiliation: | 1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing 100085, China; 2. China National Environmental Monitoring Center, Beijng 100029, China |
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| Abstract: | Polycyclic aromatic hydrocarbons which are typical persistent organic pollutants may induce lung and skin cancers in occupational settings. And the evaluation of the exposure to PAHs can provide useful data for epidemiological study and risk assessment of the pollutants. However, due to the complexity of exposure, urinary hydroxyl PAHs which are major metabolites of PAHs in human urine have been widely used as biomarkers of internal dose to evaluate the exposure to PAHs. The absorption, metabolism and the major forms of metabolites of PAHs in urine are reviewed in the paper. Furthermore several important biomarkers and factors that may cause the variation of metabolites excreted in urine are introduced. |
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| Keywords: | polycyclic aromatic hydrocarbons(PAHs) hydroxyl PAHs biomarker urine |
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