| STUDY ON THE MECHANISM OF INTERFERON ACTION (Ⅺ)——EFFECT OF pppA2'p5'A2'p5'A ON THE LEVEL OF cAMP AND cGMP IN MACROPHAGES |
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| 引用本文： | 尹桂山,杜秀全,王桂香,王学孟,张牧霞,赵文政,陈寅,姚曼华,郑宏大,刘新垣.STUDY ON THE MECHANISM OF INTERFERON ACTION (Ⅺ)——EFFECT OF pppA2''''p5''''A2''''p5''''A ON THE LEVEL OF cAMP AND cGMP IN MACROPHAGES[J].中国科学B辑(英文版),1989(8). |
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| 作者姓名： | 尹桂山 杜秀全 王桂香 王学孟 张牧霞 赵文政 陈寅 姚曼华 郑宏大 刘新垣 |
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| 作者单位： | Department of Biochemistry，Hebei Medical College，Shijiazhuang，Department of Biochemistry，Hebei Medical College，Shijiazhuang，Department of Biochemistry，Hebei Medical College，Shijiazhuang，Department of Biochemistry，Hebei Medical College，Shijiazhuang，Department of Biochemistry，Hebei Medical College，Shijiazhuang，Department of Biochemistry，Hebei Medical College，Shijiazhuang，Shanghai Institute of Biochemistry，Academia Sinica，Shanghai Institute of Biochemistry，Academia Sinica，Shanghai Institute of Biochemistry，Academia Sinica，Shanghai Institute of Biochemistry，Academia Sinica |
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| 基金项目： | the National Natural Science Foundation of China. |
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| 摘 要： | In this paper, the increase of cellular cAMP and cGMP levels in macrophages induced bypppA2'p5'A2'p5'A (briefly 2'-5'P_3A_3) is first reported. The optimal concentration of 2'-5'P_3A_3 for the elevation of cellular cGMP to the highest level is 10~(-7)-10~(-6)mol/L, while thatfor cAMP is 10~(-7)mol/L. The time for cGMP to reach its peak value is 15 min and that forcAMP is 2 h, when the cells are treated with 2'-5' P_3A_3 at 10~(-7)mol/L, which is the optimalconcentration for developing biological effect of macrophages (phagocytosis). These resultssuggest that cGMP and cAMP may be related to, or may be the mediators for, 2'-5'P_3A_3action.
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