Expedient synthesis of potent cannabinoid receptor agonist (-)-CP55,940 |
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| Authors: | Itagaki Noriaki Sugahara Tsutomu Iwabuchi Yoshiharu |
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| Institution: | Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan. |
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| Abstract: | reaction: see text] A stereocontrolled synthesis of (-)-CP55,940, a potent cannabinoid receptor agonist, has been attained using a novel aldolization/retro-aldolization interconversion strategy, in which a temporarily generated chiral aldol motif plays essential roles. |
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