Studies on the Synthesis and Dynamic NMR Properties of 2-(Benzylidene amino)-N-[(R)-2-hydroxy-2-methyl-1-phenylpropyl]acetamide |
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| Authors: | HA Samimi M Mamaghani K Tabatabeian HR Bijanzadeh |
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| Institution: | 1. Department of Chemistry, Faculty of Sciences, University of Guilan, P. O. Box 41335-1914, Rasht, Iran
2. Department of Chemistry, Tarbiat Modaress University, Tehran, Iran
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| Abstract: | An efficient method was employed for the preparation of 2-(benzylideneamino)-N-(R)-2-hydroxy-2-methyl-1-phenylpropyl] acetamide utilizing optically pure (R)-5,5-dimethyl-4-phenyloxazolidin-2-one. This product showed interesting dynamic NMR properties for the methylene protons adjacent to the azomethine group (ΔG? = 15.1 ± 0.1 kcal mol-1). |
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