Simultaneous determination of dopamine and serotonin using a carbon nanotubes-ionic liquid gel modified glassy carbon electrode |
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| Authors: | Yongxiang Sun Junjie Fei Jie Hou Qin Zhang Yanling Liu Benan Hu |
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| Institution: | 1. College of Chemistry, Xiangtan University, Xiangtan, 411105, China
2. Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, Xiangtan University, Xiangtan, 411105, China
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| Abstract: | An electrochemical sensor based on carbon nanotubes (CNTs)-ionic liquid (IL) composite has been developed for the simultaneous determination of serotonin (5-HT) and dopamine (DA). The CNTs-IL composite modified electrode presents excellent selectivity and sensitivity towards 5-HT and DA and eliminates the interference of ascorbic acid. The parameters which influence the determination of 5-HT and DA have been investigated. Under optimized conditions, linear calibration graphs were obtained in the range from 20 nM to 7 µM, with a detection of limit of 8 nM, for 5-HT, and in the range from 0.1 to 12 µM, with a detection of limit of 60 nM, for DA. The electrode has been applied to the assay of 5-HT and DA in human blood serum with good results. |
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