| 腹股沟肉芽肿的超微结构观察 |
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| 引用本文： | 潘力,崔丽,李艳茹,田歆.腹股沟肉芽肿的超微结构观察[J].电子显微学报,2008,27(4). |
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| 作者姓名： | 潘力 崔丽 李艳茹 田歆 |
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| 作者单位： | 1. 吉林大学病理生物学教育部重点实验室,吉林 长春,130021
2. 广州市皮肤病防治所,广东 广州,510095 |
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| 摘 要： | 目的:探讨腹股沟肉芽肿的组织结构和超微结构病变特征.方法:对2例腹股沟肉芽肿患者的病变组织进行光镜和透射电镜观察.结果:光镜下,肉芽肿组织内有大量巨噬细胞,其胞质内可查见革兰氏阴性的肉芽肿荚膜杆菌;透射电镜下巨噬细胞胞质内可见较大的初级溶酶体和大量形态各异、大小不等的次级溶酶体和板层样膜状结构的吞噬体(即杜诺凡小体),偶见吞噬体内有菌体剖面或其残片.结论:杜诺凡小体是巨噬细胞吞噬肉芽肿荚膜杆菌后在胞质溶酶体内形成的形态各异、大小不等的吞噬体,其超微结构形态学特征,具有临床诊断的意义.
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| 关 键 词： | 腹股沟肉芽肿 肉芽肿荚膜杆菌 巨噬细胞 溶酶体 杜诺凡小体 超微结构 |
Ultrastructural observation of granuloma inguinale |
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| PAN Li,CUI Li,LI Yan-ru,TIAN Xin.Ultrastructural observation of granuloma inguinale[J].Journal of Chinese Electron Microscopy Society,2008,27(4). |
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| Authors: | PAN Li CUI Li LI Yan-ru TIAN Xin |
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| Institution: | PAN Li~1,CUI Li~(1*),LI Yan-ru~1,TIAN Xin~2(1.The Key Laboratory of Pathobiology,Ministry of Education,Jilin University,Changchun Jilin 130021,China,2.Guangzhou Dermatosis Preventing , Curing Institute,Guangzhou Guangdong 510095,China) |
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| Abstract: | Objective:To study the histological and ultrastructural pathology of granuloma inguinale(GI).Methods:Tissues obtained from two patients with GI were observed by light microscope and electron microscope.Results:Under light microscope,the intracellular gram negative bacillus(calymmatobacterium granulomatis) could be found in cytoplasm of macrophage.There were many dense lysosomes and phagosomes of various shape and size in the cytoplasm of macrophage.Occasionary profile of bacteria or its residues could be se... |
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| Keywords: | granuloma inguinale(GI) calymmatobacterium granulomatis macrophage lysosomes Donovan body ultrastructure |
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