Highly enantioselective Michael addition of malononitrile to alpha,beta-unsaturated ketones |
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| Authors: | Li Xuefeng Cun Lingfeng Lian Chunxia Zhong Ling Chen Yingchun Liao Jian Zhu Jin Deng Jingen |
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| Affiliation: | National Engineering Research Center of Chiral Drugs and Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, The Chinese Academy of Sciences, Chengdu 610041, China. |
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| Abstract: | The highly enantioselective Michael addition of malononitrile to acyclic and cyclic alpha,beta-unsaturated ketones has been developed. The Michael reaction catalyzed by a primary amine derived from quinidine proceeded smoothly and provided the desired adducts with excellent enantioselectivities (83-97% ee). |
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