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| 4-(3-吲哚基)-3-丁烯-2-酮苯甲酰腙Schiff碱过渡金属配合物的合成、表征及生物活性研究 | |
| 引用本文： | 孙纲春,曲建强,王流芳,陈耐生,李燕,陈晓光,谢晶曦.4-(3-吲哚基)-3-丁烯-2-酮苯甲酰腙Schiff碱过渡金属配合物的合成、表征及生物活性研究[J].无机化学学报,2005,21(7):1069-1072. |
| 作者姓名： | 孙纲春 曲建强 王流芳 陈耐生 李燕 陈晓光 谢晶曦 |
| 作者单位： | 1. 福州大学功能材料研究所,福州,350002 2. 兰州大学应用有机化学国家重点实验室,兰州,730000;天津大学化学系 3. 兰州大学应用有机化学国家重点实验室,兰州,730000 4. 中国医学科学院,中国协和医科大学药物研究所,北京,100050 |
| 基金项目： | 国家自然科学基金资助项目(No.50272027)。 |
| 摘 要： | A Schiff base ligand 4-indol-3-yl]-but-3-en-2-one benzoyl hydrazone (HL), and its four transition metal complexes (ML2，M=Cu(Ⅱ), Ni(Ⅱ), Zn(Ⅱ) and Co(Ⅱ)) have been prepared and characterized by means of elemental analysis, EI-MS, molar conductivity, IR, UV-Vis and 1H NMR. The results showed that HL as a bidentate ligand coordinated with transition metal ions to form four-coordination complexes. The antibacterial activity was studied by using the filter scraps diffusion method, and the results indicated that the ligand and the complexes had a low bacteriostatic activity against S. Aureu, P. Aeruginosa and E. Coli. The low in vitro antitumor activity of the title complexes was also observed by using MTT method against KB, A2780, Bel7402 and HELF. |
| 关 键 词： | 席夫碱 过渡金属配合物 合成 表征 生物活性 |
| 文章编号： | 1001-4861(2005)07-1069-04 |
| 收稿时间： | 2004/11/15 0:00:00 |
| 修稿时间： | 2004年11月15 |
Synthesis, Characterization and Biological Activities of Transition Metal Complexes with Schiff Base Ligand 4-[Indol-3-yl]-but-3-en-2-one Benzoyl Hydrazone |
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| SUN Gang-Chun,QU Jian-Qiang,WANG Liu-Fang,CHEN Nai-Sheng,LI Yan,CHEN Xiao-Guang and XIE Jing-Xi.Synthesis, Characterization and Biological Activities of Transition Metal Complexes with Schiff Base Ligand 4-[Indol-3-yl]-but-3-en-2-one Benzoyl Hydrazone[J].Chinese Journal of Inorganic Chemistry,2005,21(7):1069-1072. | |
| Authors: | SUN Gang-Chun QU Jian-Qiang WANG Liu-Fang CHEN Nai-Sheng LI Yan CHEN Xiao-Guang and XIE Jing-Xi |
| Institution: | Institute of Functional Matreials, Fuzhou University, Fuzhou 350002,State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000,State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000,Institute of Functional Matreials, Fuzhou University, Fuzhou 350002,Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050,Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050 and Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050 |
| Abstract: | |
| Keywords: | Schiff base transition metal complex synthesis characterization biological activity |
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