Synthesis of functionalized quinolines via Ugi and Pd-catalyzed intramolecular arylation reactions |
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| Authors: | Ma Zhibo Xiang Zheng Luo Tuoping Lu Kui Xu Zhibin Chen Jiahua Yang Zhen |
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| Institution: | Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing, China 100871. |
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| Abstract: | Two types of quinoline scaffolds were constructed in a combinatorial format via the Ugi four-component reaction (U-4CR) and Pd-catalyzed intramolecular arylation reaction. The scope of this two-step synthetic sequence was examined from commercially available and synthetically accessible starting materials. |
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