Select cognitive deficits in Vasoactive Intestinal Peptide deficient mice |
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| Authors: | Dipesh Chaudhury Dawn H Loh Joanna M Dragich Arkady Hagopian Christopher S Colwell |
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| Institution: | (1) Department of Psychiatry and Biobehavioral Sciences, University of California – Los Angeles, 760 Westwood Plaza, 90024-1759 Los Angeles, California, USA;(2) Department of Neurobiology and Behavior, W257 Seeley G MuddBioscience Wing, Cornell University, 14850 Ithaca, New York, USA |
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| Abstract: | Background The neuropeptide vasoactive intestinal peptide (VIP) is widely distributed in the adult central nervous system where this
peptide functions to regulate synaptic transmission and neural excitability. The expression of VIP and its receptors in brain
regions implicated in learning and memory functions, including the hippocampus, cortex, and amygdala, raise the possibility
that this peptide may function to modulate learned behaviors. Among other actions, the loss of VIP has a profound effect on
circadian timing and may specifically influence the temporal regulation of learning and memory functions. |
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