| 急性缺氧条件下EP、CM、CAP以及耳蜗毛细胞的形态学变化 |
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| 引用本文： | 李兴启, 孙建和, 孙伟, 姜泗长. 急性缺氧条件下EP、CM、CAP以及耳蜗毛细胞的形态学变化[J]. 声学学报, 1995, 20(1): 72-77. DOI: 10.15949/j.cnki.0371-0025.1995.01.010 |
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| 作者姓名： | 李兴启 孙建和 孙伟 姜泗长 |
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| 作者单位： | 中国人民解放军总医院耳鼻咽喉科，中国人民解放军耳鼻咽喉科研究所 |
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| 摘 要： | 本实验用同一根玻璃微电极在豚鼠耳蜗中阶记录EP（Endocochlear Potential，耳蜗内电位）、CM（Cochlear Microphonics，耳蜗振电压）、CAP（Comnound Action Potential，复合动作电位），观察在不同缺氧状态下，三者动态变化过程.发现在缺氧初始（1-2分钟），CM和CAP随EP同步迅速下降；但缺氧3-6分钟时，CM下降缓慢，似一
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| 收稿时间： | 1993-11-09 |
Changes in endocochlear potential,cochlear microphonics,compound action potential and the morphology of Hair cells in guinea pig during acute anoxia |
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| LI Xingqi, SUN Jianhe, SUN Wei, JIANG Sizhang. Changes in endocochlear potential, cochlear microphonics, compound action potential and the morphology of Hair cells in guinea pig during acute anoxia[J]. ACTA ACUSTICA, 1995, 20(1): 72-77. DOI: 10.15949/j.cnki.0371-0025.1995.01.010 |
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| Authors: | LI Xingqi SUN Jianhe SUN Wei JIANG Sizhang |
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| Abstract: | Endocochlear Potential (EP), Cochlear Microphonics (CM), Compound Action Potential(CAP) were recorded from scala media of guinea pig's cochlear the second turn with the same microelectrode,CM and CAP droped rapidly with EP in 1-2 minute in anoxia. In 3-6 minutes, CM droped slowly, forming a platform. While CAP and EP droped continuously. In 7-12 minutes CM droped in parallel with CAP and EP. Scanning electronic microscope declare:the mild damage of the spiral organ due to anoxia. The secretive and global substance on the inner hair cell's (IHC) surface are observed. The defined secretion of global substance on outer hair cells (OHC) and fusedstereocilia are also seen. The results show f the function of OHC and IHC are related with metabolism of Oxygen. The change in CM was affected directly by OHC and IHC damage. CM platform in anoxia is probably related with the piezoelectric effect of tectorial membrance. |
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