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IR and Raman spectral and X-ray structural studies of polymorphic forms of sulfamethoxazole
Institution:1. Zeolites Engineering Laboratory, Institute of Materials Science and Technology (IMRE), University of Havana, Cuba;2. Department of Pharmacy, Institute of Pharmacy and Food (IFAL), University of Havana, Cuba;3. Institut Charles Gerhardt Montpellier, Equipe Agrégats, Interface, et Matériaux pour l''Energie (AIME), Université Montpellier 2, France;4. Faculty of Physics, Adam Mickiewicz University, Poland
Abstract:The crystal structure of the polymorphic form III (hemihydrate) of sulfamethoxazole (SMZ) was determined to exist in both the E- and Z-forms by X-ray analysis and was compared with the polymorphic forms I and II which are known to exist in the E-form. IR spectra of IIII and their corresponding forms IDIIID which contain the deuterated amino and amido groups and D2O and Raman spectra of IIII have been measured. For IIII, assignment of the stretching vibration ν(NH) and ν(CH)] bands of amino and amido groups and the CH bond of the isoxazole ring involved in the inter-molecular hydrogen bonds has been proposed based on consideration of the IR and Raman spectra and the results of X-ray analysis. A relationship was established between the relative intensity and wavenumbers for the ν(CH) band in the inter-molecular C(sp2)H?X hydrogen bond of the E-form.
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