Design and synthesis of useful intermediates for novel lipoxygenase substrates through enzymatic resolution |
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| Affiliation: | 1. Graduate School of Logistics, Inha University, 100 Inharo, Namgu, Incheon 402-751, Republic of Korea;2. Institute of Blue and Green Development Shandong University, Weihai, 264200, PR China;3. Department of Economics, Jinan University, No. 601, West of Huangpu Avenue, Tianhe District, Guangzhou, Guangdong 510632, China |
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| Abstract: | Unnatural lipoxygenase substrates carrying spacing modifiers with a non-ionic hydroxy terminus and with methylene (flanked by the cis,cis diene moiety) pro-(S)-hydrogen can be synthesized from the intermediates 1a–1c. These intermediates are conveniently synthesized via enzymatic resolution with lipase in organic solvents. |
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