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Asymmetric synthesis of fagomine and its congeners
Affiliation:1. State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China;2. Key Laboratory of Biopesticide and Chemical Biology of Ministry of Education, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China;3. State Key Laboratory of Microbial Metabolism, Joint International Laboratory on Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China;1. Universidad de los Andes, Department of Electrical and Electronic Engineering, Bogota, Colombia;2. CentraleSup - lec, GeePs - Gnie lectrique et lectronique de Paris, Gif-sur-Yvette, France
Abstract:The total synthesis of fagomine and its congeners 13 has been achieved starting from d-serine-derived Garner aldehyde 5 by catalytic ring-closing metathesis (RCM) for the construction of the piperidine ring followed by dihydroxylation.
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