(R)-Oxynitrilase-catalyzed hydrocyanation: the first synthesis of optically active fluorinated mandelonitriles |
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| Affiliation: | 1. Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China;2. University of Chinese Academy of Sciences, Beijing 100043, PR China;1. Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok, 10210, Thailand;2. Chulabhorn Graduate Institute, Chemical Biology Program, Chulabhorn Royal Academy, Kamphaeng Phet 6 Rood, Laksi, Bangkok, 10210, Thailand;3. Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok, Thailand;4. Laboratory of Natural Products Chemistry, Faculty of Science and Technology, Phuket Rajabhat University, Phuket, 83000, Thailand;1. N.N. Semenov Institute of Chemical Physics RAS, Russia;2. Department of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia;3. Department of Physics, M.V. Lomonosov Moscow State University, Moscow, Russia;1. Pharmaceutical Chemistry, School of Pharmacy, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa;2. Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa |
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| Abstract: | The first enantioselective synthesis of (R)-fluorinated mandelonitriles, by hydrocyanation under micro-aqueous conditions with almond meal as catalyst is reported. |
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