A new and rapid access to homochiral 2,3-dihydro-oxazolo[2,3-b]quinazolin-5-ones |
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| Affiliation: | 1. Institut de Chimie Organique et Analytique, Université d''Orléans, B.P. 6759, F-45067 Orléans, France;2. Istituto Sperimentale per le Colture Industriali, MiPA, via di Corticella 133, I-40129 Bologna, Italy;1. The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, PR China;2. Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, PR China |
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| Abstract: | Starting from homochiral 1,3-oxazolidine-2-thiones 1, a two-step sequence led to homotopic 2,3-dihydro-oxazolo[2,3-b]quinazolin-5-one derivatives 3. The sequence was developed and studied regarding its scope and limitations. |
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