Stereocontrolled chemoenzymatic synthesis of 2,3-disubstituted piperidines |
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| Institution: | 1. Radiology & Nuclear Medicine, VU University Medical Center, 1081, HV, Amsterdam, The Netherlands;2. Anatomy & Neurosciences, VU University Medical Center, 1081, HV, Amsterdam, The Netherlands;3. ZEDIRA GmbH, D-64293, Darmstadt, Germany |
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| Abstract: | (R,R)-2,3-Disubstituted piperidines were readily synthesized starting from (R)-(+)-5-bromo-2-hydroxypentanenitrile (R)-2. An enantioselective (R)-oxynitrilase-catalyzed transcyanation was used to prepare the starting cyanohydrin (R)-2. |
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