An enzyme-triggered enantio-convergent cascade-reaction |
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| Institution: | 1. Laboratory of Selective Organic Chemistry & Biological Activity, Department of Chemistry, Faculty of Science, University of Tunis El Manar, 2092, Tunisia;2. Laboratory of Materials and Crystallochemistry, Department of Chemistry, Faculty of Science, University of Tunis El Manar, 2092, Tunisia;3. Laboratory of Physical Chemistry of Condensed Materials, Department of Chemistry, Faculty of Science, University of Tunis El Manar, 2092, Tunisia;4. Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, FL 34987, United States;5. Florida Atlantic University, Boca Raton, FL 33431, USA;1. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa;2. Center for Organic Chemistry C.D. Nenitescu, Romanian Academy, Spl. Independentei 202B, Bucharest 060023, Romania;3. Faculty of Applied Chemistry and Materials Science, ‘Politehnica’ University of Bucharest, Polizu Street 1-7, 011061 Bucharest, Romania;4. Faculty of Pharmacy, ‘Ovidius’ University, Aleea Universitatii nr.1, Campus Corp B, Constantza 900470, Romania;1. Department of Physics, Faculty of Sciences, King Abdulaziz University, Saudi Arabia;2. Department of Material Science and Engineering, Faculty of Engineering, Izmir Katip Celebi University, Turkey |
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| Abstract: | The biocatalytic hydrolysis of the (±)-2,3-disubstituted cis-chloroalkyl epoxides 1a and 2a using resting cells of Rhodococcus sp. did not give the corresponding chloroalkyl vic-diols 1b, and 2b, respectively, but furnished the rearranged products (2R,3R)-1c and (2R,3R)-2c in high e.e. as the sole products via an enzyme-triggered enantio-convergent cascade-reaction. |
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