Synthesis and antitumor activity of 7-(N-glycosylamino)-indolo[3,2-b]quinolines |
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| Authors: | Y Takeuchi M R Chang K Hashigaki M Yamato |
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| Institution: | Faculty of Pharmaceutical Sciences, Okayama University, Japan. |
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| Abstract: | Novel indolo3,2-b]quinolines (1d-g), introduced at the 7-position with an N-glycosylamino group, were prepared and their antitumor activities against leukemia P388 in mice were examined. The N-Galactopyranosylamino derivative (1e) was a much more potent anti-leukemia compound (optimal dose = 25 mg/kg, T/C greater than 333%, cure 5/6) than lead compound 1a. |
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