Synthesis and Antibacterial Activities of Pyran Annulated Heterocyclic Compounds |
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| Authors: | QU Di LIU Zhen LI Jing LUO Xiao-Xing LI Ming-Kai |
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| Institution: | 1. Department of Pharmacology, School of Pharmacy,the Fourth Military Medical University, Xi'an 710032, China
2. School of Chemistry and Chemical Engineering, Xi'an University, Xi'an 710065, China |
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| Abstract: | Two novel pyran annulated heterocyclic compounds(1 and 2) were synthesized and characterized via IR, 1H NMR and H RMS. The structure of compound 1 was verified by single-crystal X-ray diffraction. The in vitro antibacterial activities of the two compounds against Staphylococcus aureus(S. aureus ATCC 29213), methicillin-resistant S. aureus(MRSA XJ 75302), vancomycin-intermediate S. aureus(Mu50 ATCC 700699), and USA 300(Los Angeles County clone, LAC) were evaluated by observing the minimum inhibitory concentration. |
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| Keywords: | pyran crystal staphylococcus aureus minimum inhibitory concentration |
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