酚类环境雌激素的分析研究进展

环境中分布或残留的化学物质对人类和野生动物的内分泌系统的不良影响已引起广泛关注。在已发现的数十种环境内分泌干扰物中，壬基苯酚、辛基苯酚、双酚A和2，4－二氯酚等以其相似的结构特征和类雌激素活性逐渐被划分为一类新的分析研究对象，称为酚类环境雌激素。本文综述了这些物质的主要来源和分布及其分析测定的研究进展，重点评述了一些新的分析技术如基体固相分散萃取法（MSPD）、分子印迹聚合物法（MIP）、荧光分子传感法（FMS）和生物识别－化学分析联用法等在上述物质的分析测定中的应用。比较了GC－MS和LC－MS等手段用于分析此类物质的优势和各自的局限性，并展望了这一领域未来的研究发展趋势。本文引用文献共54篇。

The Analysis of Phenolic Environmental Estrogens

It has been found that many industrial chemicals present in the environment have adverse effects on the endocrine systems in humans and wild animals. Among the tens of endocrine disrupting chemicals (EDCs) identified so far, alkylphenols (including 4 nonylphenol and 4 t octylphenol), bisphenol A and 2,4 dichlorophenol are often studied as a group of phenolic environmental estrogens due to their structural and estrogenic similarities. In this paper, the main sources, weak estrogenic property and analytical methods for these substances in the environment were reviewed based on 54 literatures. Some newly developed techniques such as Matrix Solid Phase Dispersion(MSPD), molecular imprinted polymer(MIP), fluorescence molecular sensing(FMS)and combination of biological recognition and chemical analysis were overviewed for their application in the analysis of above mentioned substances. The advantages and limitations of gas chromatography mass spectrometry and liquid chromatography mass spectrometry used for the determination of phenolic environmental estrogens were summarized. The trend for the future research in this field was also briefly discussed.