| 丙磺舒药物键合两亲共聚物的制备 |
| |
| 引用本文： | 吴正翠,李庆海,方向,沈良骏. 丙磺舒药物键合两亲共聚物的制备[J]. 应用化学, 2004, 21(12): 1257-0 |
| |
| 作者姓名： | 吴正翠 李庆海 方向 沈良骏 |
| |
| 作者单位： | 安徽师范大学，安徽工程科技学院 |
| |
| 基金项目： | 安徽省教育厅自然科学基金 ( 2 0 0 3kj14 7)，安徽工程科技学院青年科研基金 ( 2 0 0 2YQ0 0 4)资助项目 |
| |
| 摘 要： | 丙磺舒药物键合两亲共聚物的制备;丙磺舒; 两亲共聚物; 高分子药物
|
| 关 键 词： | 丙磺舒药物键合两亲共聚物的制备 丙磺舒 两亲共聚物 高分子药物 |
| 文章编号： | 1000-0518(2004)12-1257-04 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2003-12-31 |
Synthesis of Amphiphilic Macromolecular Prodrugs Anchored with Probenecid |
| |
| WU Zheng-Cui a,LI Qing-Hai b,FANG Xiang a,SHEN Liang-Jun a. Synthesis of Amphiphilic Macromolecular Prodrugs Anchored with Probenecid[J]. Chinese Journal of Applied Chemistry, 2004, 21(12): 1257-0 |
| |
| Authors: | WU Zheng-Cui a LI Qing-Hai b FANG Xiang a SHEN Liang-Jun a |
| |
| Affiliation: | WU Zheng-Cui a*,LI Qing-Hai b,FANG Xiang a,SHEN Liang-Jun a |
| |
| Abstract: | A nonsteroidal antiinflammatory drug, probenecid, was covalently linked with 2-hydroxyethyl methacrylate(HEMA) through esterification reaction. The drug-linked HEMA(abbreviated as HP) was copolymerized with polyoxyethylene macromers(PEO-MA) to obtain macromolecular prodrugs using azobisisobutyronitrile(AIBN) as an initiator. The polymer was characterized with IR, 1H NMR and GPC. The effect of initiator amount and the ratio of drug to monomer were discussed. Increasing the amount of AIBN decreased the molecular weight of the copolymer. Increasing HP content in monomers increased probenecid content in the copolymer. |
| |
| Keywords: | probenecid amphiphilic copolymer macromolecular prodrug |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《应用化学》浏览原始摘要信息 |
|
点击此处可从《应用化学》下载全文 |
