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| 水相中2-氨基-4-芳基-5,6-二氢化-4H-吡喃并[3,2-c]喹啉-5-酮衍生物的合成 | |
| 引用本文： | 王香善,曾兆森,李玉玲,史达清,屠树江,魏贤勇,宗志敏. 水相中2-氨基-4-芳基-5,6-二氢化-4H-吡喃并[3,2-c]喹啉-5-酮衍生物的合成[J]. 有机化学, 2006, 26(2): 228-232 |
| 作者姓名： | 王香善 曾兆森 李玉玲 史达清 屠树江 魏贤勇 宗志敏 |
| 作者单位： | 1. 徐州师范大学化学系,徐州,221116;中国矿业大学化学工程学院,徐州,221008;江苏省药用植物生物技术重点实验室,徐州,221116 2. 徐州师范大学化学系,徐州,221116 3. 徐州师范大学化学系,徐州,221116;江苏省药用植物生物技术重点实验室,徐州,221116 4. 中国矿业大学化学工程学院,徐州,221008 |
| 基金项目： | 江苏省高校自然科学基金(No.04KJB150139)资助项目. |
| 摘 要： | 以芳亚甲基丙二腈或2-氰基-3-芳基丙烯酸酯和4-羟基喹啉-2-酮为原料, 水为溶剂, 在TEBA(三乙基苄基氯化铵)催化下90 ℃, 合成了2-氨基-4-芳基-5,6-二氢化-4H-吡喃[3,2-c]喹啉-5-酮衍生物. 和其它方法相比, 该反应具有反应条件温和, 产率高(87%～96%)和环境友好等优点. 产物的结构通过熔点, IR, 1H NMR和元素分析表征. 化合物3m的结构通过X单晶衍射分析确证. |
| 关 键 词： | 吡喃并喹啉 水 TEBA 合成 |
| 收稿时间： | 2005-02-23 |
| 修稿时间： | 2005-04-06 |
Synthesis of 2-Amino-4-aryl-5,6-dihydro-4H-pyrano[3,2-c]quinolin-5-one Derivatives in Water |
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| WANG, Xiang-Shan,ZENG, Zhao-Sen,LI, Yu-Ling,SHI, Da-Qing,TU, Shu-Jiang,WEI, Xian-Yong,ZONG, Zhi-Min. Synthesis of 2-Amino-4-aryl-5,6-dihydro-4H-pyrano[3,2-c]quinolin-5-one Derivatives in Water[J]. Chinese Journal of Organic Chemistry, 2006, 26(2): 228-232 | |
| Authors: | WANG Xiang-Shan ZENG Zhao-Sen LI Yu-Ling SHI Da-Qing TU Shu-Jiang WEI Xian-Yong ZONG Zhi-Min |
| Affiliation: | a Department of Chemistry, Xuzhou Normal University, Xuzhou 221116;b School of Chemical Engineering, China University of Mining and Technology, Xuzhou 221008;c Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou 221116 |
| Abstract: | A series of 2-amino-4-aryl-5,6-dihydro-4H-pyrano[3,2-c]quinolin-5-one derivatives were synthesized by the TEBA (triethylbenzyl ammonium chloride) catalyzed reaction of arylmethylidenemalononitriles or 3-aryl-2-cyano-1-acrylate with 4-hydroxy-1,2-dihydroquinolin-2-one in water at 90 ℃. Compared with other synthetic methods, this method has the advantages of milder reaction conditions, high yields (87%～96%) and environmentally benign procedure. The structures of the products were characterized by melting points, IR, 1H NMR spectra and elemental analysis, and the structure of compond 3m was confirmed by X-ray diffraction analysis. |
| Keywords: | pyranoquinoline water TEBA synthesis |
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