| 5-阿维菌素B1a酯的合成及生物活性 |
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| 引用本文： | 廖联安,李正名,方红云,赵卫光,陈明德,范志金,刘桂龙. 5-阿维菌素B1a酯的合成及生物活性[J]. 高等学校化学学报, 2002, 23(9): 1709-1714 |
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| 作者姓名： | 廖联安 李正名 方红云 赵卫光 陈明德 范志金 刘桂龙 |
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| 作者单位： | 1. 厦门大学化学系, 厦门 361005;2. 南开大学元素有机化学研究所, 元素有机化学国家重点实验室, 天津 300071 |
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| 基金项目： | 国家高技术研究发展计划(863计划)，29832050， |
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| 摘 要： | 阿维菌素B1a(AVB1a)与羧酸在DMAP/DCC体系中直接酯化,得到10个5-AVB1a酯衍生物,产率50%～79%;其化学结构由IR,1H NMR,13CNMR和MS谱确证.生物活性测定结果表明,部分5-阿维菌素B1a酯衍生物具有良好的杀虫、杀螨活性.
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| 关 键 词： | 5-阿维菌素B1a酯 生物活性 酯化 DMAP/DCC |
| 文章编号： | 0251-0790(2002)09-1709-06 |
| 收稿时间： | 2001-06-18 |
Synthesis and Bioactivity of 5-Avermectin B1a Esters |
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| LIAO Lian An ,LI Zheng Ming ,FANG Hong Yun ,ZHAO Wei Guang ,CHEN Ming De ,FAN Zhi Jin ,LIU Gui Long. Synthesis and Bioactivity of 5-Avermectin B1a Esters[J]. Chemical Research In Chinese Universities, 2002, 23(9): 1709-1714 |
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| Authors: | LIAO Lian An LI Zheng Ming FANG Hong Yun ZHAO Wei Guang CHEN Ming De FAN Zhi Jin LIU Gui Long |
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| Affiliation: | 1. Depa rtment of Chemistry, Xiamen University, Xiamen 361005, China;2. Instituteof Emento-organic Chemistry, State Key Laboratoryof Elemento-Organic Chemistry, Nanka i University, Tianjin 300071, China |
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| Abstract: | Ten 5 Avermectin B 1a ester derivatives were prepared from avermectin B 1a and carboxylic acids in the systems of DCC/DMAP. Their chemical structures were confirmed by IR, 1H NMR, { 13 C NMR} and MS. Their insecticidal activity was evaluated against Aphis gossypii Glover and Tetranychus truncatus Ehara. It was found that some compounds showed a higher insecticidal activity than Avermectin. |
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| Keywords: | Avermectin B 1a Bioactivity Esterification DMAP/DCC |
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