Synthesis of novel 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines as potential protein kinase inhibitors |
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Authors: | Marko P Su?nik Michael Schnürch Marko D Mihovilovic Kurt Mereiter Peter Stanetty |
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Institution: | (1) Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, 1060 Vienna, Austria;(2) Institute for Chemical Technology and Analytics, Vienna University of Technology, Getreidemarkt 9/164, 1060 Vienna, Austria |
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Abstract: | Abstract A short and efficient sequence for the synthesis of a series of 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines was developed.
1-Phenyl-2-(6-pyrimidinyl)-ethanones, obtained via Weinreb’s methodology, were used in a Hantzsch thiazole cyclization reaction,
followed by introduction of the aniline moieties via nucleophilic substitution.
Graphical abstract
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Keywords: | Fungicides Heterocycles Nucleophilic aromatic substitutions Cyclizations Weinreb amide |
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