人乳头瘤病毒16及18型E6与p53表达的关系

采用 SP免疫组织化学方法 ,比较了 6 8例宫颈癌组织中 HPV- 16、18E6和 p5 3蛋白的表达及其相互关系 .结果表明 ,6 8例宫颈癌中有 6 0例 HPV - 16、18E6蛋白和 17例 p5 3蛋白呈阳性表达 ,阳性率分别为 88.2 %和2 5 .0 % ;在 5 9例 HPV- 16、18E6蛋白过度表达的宫颈癌中有 5 4例 p5 3蛋白为阴性或弱阳性表达 ,二者呈负相关(P <0 .0 1) .p5 3蛋白阳性表达与组织学类型有关 ,其阳性率在宫颈腺癌中为 83.3%和宫颈鳞癌中为 17.2 % ,差异有极显著意义 (P <0 .0 1) .p5 3蛋白阳性表达随着临床分期上升而增高 .

The Relationship Between Human Papillomavirus Types 16,18 E6 and p53 Expression in Cervical Carcinoma

Immunohistochemistry SP method was used to study the relation between HPV types 16,18 E6 and p53 protein expression in 68 cases of cervical carcinomas. The results show HPV\|16,18 E6 and p53 protein positive expression were detected in 60 and 17 of 68 cervical carcinomas, positive rates of HPV\|16,18 E6, p53 protein were 88.2% and 25.0% respectively; overexpression of HPV\|16,18 E6 protein were revealed in 59 cases of cervical carcinomas with p53 negative and poor positive expression in 54 cases, the both showed a negative corretation(P<0.01). Expression of p53 was associated with histological types, its positive rate was 83.3% in adenocarcinoma and 17.2% in squamous cell carcinoma, there was a significant difference between adenocarcinoma and squamous cell carcinoma(P<0.01).Positive expression of p53 was higher as clinical stage increased(P<0.01).