Large Scale Bioprocess for the Production of Optically Pure L-Carnitine |
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Authors: | Hans-Peter Meyer and Karen T Robins |
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Abstract: | A competitive production method using the biotransformation of 4-butyrobetaine to enantiomerically pure L-carnitine was developed and scaled-up by Lonza. The process produces L-carnitine in 99.5% yield, and >99.9% enantiomeric excess (ee). Continuous and discontinuous processes were developed but the fed-batch process was found to be economically the most favourable process mode. |
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