Prevalence of legal and illegal stimulating agents in sports |
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Authors: | K Deventer K Roels F T Delbeke P Van Eenoo |
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Institution: | (1) DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, 9052 Gent, Belgium;(2) DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, 9052 Zwijnaarde, Belgium |
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Abstract: | This paper reviews the prevalence of legal and illegal stimulants in relation to doping-control analysis. Stimulants are among
the oldest classes of doping agents, having been used since ancient times. Despite the ease with which they can be detected
and the availability of sensitive detection methods, stimulants are still popular among athletes. Indeed, they remain one
of the top three most popular classes of prohibited substances. Because the list of legal and illegal stimulants is extensive
only a selection is discussed in detail. The compounds selected are caffeine, ephedrines, amphetamine and related compounds,
methylphenidate, cocaine, strychnine, modafinil, adrafinil, 4-methyl-2-hexaneamine, and sibutramine. These compounds are mainly
prevalent in sport or are of therapeutic importance. Because stimulants are the oldest doping class the first detection methods
were for this group. Several early detection techniques including GC–NPD, GC–ECD, and TLC are highlighted. The more novel
detection techniques GC–MS and LC–MS are also discussed in detail. In particular, the last technique has been shown to enable
successful detection of stimulants difficult to detect by GC–MS or for stimulants previously undetectable. Because stimulants
are also regularly detected in nutritional (food) supplements a section on this topic is also included. |
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