| 4H-吡啶并[3,2-e][1,3]噻嗪-4-酮嘧啶衍生物的合成 |
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| 引用本文： | 孙晓红,吉鹏举,刘源发,陈邦,贾婴琦. 4H-吡啶并[3,2-e][1,3]噻嗪-4-酮嘧啶衍生物的合成[J]. 有机化学, 2005, 25(6): 724-726 |
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| 作者姓名： | 孙晓红 吉鹏举 刘源发 陈邦 贾婴琦 |
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| 作者单位： | 1. 西北大学化学研究所,西安,710069
2. 西北大学化学系,西安,710069 |
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| 摘 要： | 2-氯烟酸异硫氰酸酯在碱性介质中与取代2-氨基嘧啶反应直接得到4H-吡啶并[3,2-e][1,3]噻嗪-4-酮嘧啶. 所合成的6个未见文献报道的目标化合物经IR, 1H NMR和元素分析证实了其结构, 并对反应可能机理进行了探讨.
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| 关 键 词： | 异硫氰酸酯 取代2-氨基嘧啶 4H-吡啶并[3,2-e][1,3]噻嗪-4-酮嘧啶 合成 |
| 收稿时间： | 2004-07-01 |
| 修稿时间： | 2004-07-01 |
Synthesis of 2-(Pyrimidin-2-yl)amino-4H-pyrido[3,2-e]-[1,3]thiazin-4-one Derivatives |
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| SUN,Xiao-Hong,JI,Peng-Jua,LIU,Yuan-Fa,CHEN,Bang,JIA,Ying-Qi. Synthesis of 2-(Pyrimidin-2-yl)amino-4H-pyrido[3,2-e]-[1,3]thiazin-4-one Derivatives[J]. Chinese Journal of Organic Chemistry, 2005, 25(6): 724-726 |
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| Authors: | SUN Xiao-Hong JI Peng-Jua LIU Yuan-Fa CHEN Bang JIA Ying-Qi |
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| Affiliation: | (Institute of Chemistry, Northwest University, Xi'an 710069)(Department of Chemistry, Northwest University, Xi'an 710069) |
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| Abstract: | 2-Chloronicotioyl isothiocyanate reacted with substituted 2-aminopyrimidine under the alkali condition to give 2-(pyrimidin-2-yl)amino-4H-pyrido[3,2-e][1,3]thiazin-4-one directly. Six 2-(pyrimidin-2- yl)amino-4H-pyrido[3,2-e][1,3]thiazin-4-one compounds were synthesized. The structures of these com- pounds were confirmed by IR, 1H NMR spectra and elemental analyses. A possible mechanism of the reac- tion was proposed. |
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| Keywords: | isothiocyanate substituted 2-aminopyrimidine 2-(pyrimidin-2-yl)amino-4H-pyrido-[3 2-e]- [1 3]thiazin-4-one synthesis |
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