Transition metal salt-catalyzed direct three-component mannich reactions of aldehydes, ketones, and carbamates: efficient synthesis of N-protected beta-aryl-beta-amino ketone compounds |
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Authors: | Xu Li-Wen Xia Chun-Gu Li Lyi |
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Institution: | State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PRC. |
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Abstract: | The transition metal salt-catalyzed direct three-component Mannich reactions of aryl aldehydes, aryl ketones, and carbamates are described. The RuCl(3).xH(2)O-, AuCl(3)-PPh(3)-, and AuCl(3)-catalyzed direct Mannich reactions led to the synthesis of N-protected beta-aryl-beta-amino ketones, and the results create new possibilities for exploiting the transition metal salt-catalyzed direct Mannich reaction and facile synthesis of beta-amino ketone libraries. |
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