UV light induced photodegradation of liposome encapsulated fluoroquinolones: An MS study |
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| Authors: | Marianna Budai Pl Grf Andreas Zimmer Katalin Ppai Imre Klebovich Krisztina Ludnyi |
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| Institution: | aSemmelweis University, Department of Pharmaceutics, Hőgyes u. 7, H-1092 Budapest, Hungary;bSemmelweis University, Institute of Biophysics and Radiation Biology, Puskin u. 9, H-1088 Budapest, Hungary;cKarl-Franzens-University, Department of Pharmaceutical Technology, Schubert Str. 6, A-8010 Graz, Austria |
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| Abstract: | Fluoroquinolone antibacterial agents are among the drugs most commonly causing phototoxic side effects. The phototoxicity may be originated in formation of reactive oxygen species upon ultraviolet exposure. Researches aiming the liposomal encapsulation of fluoroquinolones, expecting an increase in their therapeutic index, enhance the importance of studies on physicochemical properties and photostability of liposomal preparations. We studied the photodegradation of ciprofloxacin, ofloxacin and lomefloxacin by mass spectrometry upon various doses of UV irradiation. Lomefloxacin, the most phototoxic fluoroquinolone among them, was encapsulated into small unilamellar and multilamellar liposomes. Impact of vesicle structure and lipid composition – the presence of unsaturated fatty acid containing dioleoyl-phosphatidylcholine in dipalmitoyl-phosphatidylcholine liposomes – on the lomefloxacin photolysis was investigated; the structure of the main photoproducts was identified by mass spectrometry. It was found that the presence and type of lipids influence the ways of photodegradation process. |
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| Keywords: | Fluoroquinolone Liposome Photodegradation Mass spectrometry UV |
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