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Robust stability of Switched Boolean Networks with function perturbation
Abstract:In genetic regulatory networks, gene mutations are one of natural phenomena, which attract much attention by biological researchers. In modeling gene networks using switched Boolean networks (SBNs), gene mutations can be described by function perturbations, which is a meaningful issue in analyzing function perturbation of SBNs. This paper studies robust stability of SBNs with function perturbation. With the help of semi-tensor product (STP) of matrices, one equivalent algebraic form of SBNs is established. By constructing two state sets, a criterion for global stability of SBNs under arbitrary switching signals is proposed. In order to relax the conditions of global stability, pointwise stabilizability and consistent stabilizability of SBNs are further considered. Based on state reachable sets, several criteria are established for the proposed kinds of stability. Finally, the obtained results are verified by two examples and lac operon in the Escherichia coli, respectively.
Keywords:Switched Boolean Networks  Semi-tensor product of matrices  Algebraic state space representation  Robust stability  Function perturbation
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