Organocatalytic and enantioselective synthesis of beta-(hydroxyalkyl)-gamma-butyrolactones |
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| Authors: | Hajra Saumen Giri Aswini Kumar |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology, Kharagpur, India. shajra@chem.iitkgp.ernet.in |
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| Abstract: | Organocatalytic cross-aldol reaction of methyl 4-oxobutyrate (2) and a variety of aldehydes 3 followed by reduction with NaBH(4) has provided a one-pot, general and efficient method for the synthesis of 4-(hydroxyalkyl)-gamma-butyrolactones 1 with high diastereo-(dr > 24:1) and enantioselectivity (ee > 99%). |
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