|
|||||
|
|
IN VITRO AND IN VIVO PROTECTION AGAINST PHOTOTOXIC SIDE EFFECTS OF PHOTODYNAMIC THERAPY BY RADIOPROTECTIVE AGENTSWR–2721 ANDWR–77913 |
|
| Authors: | James Dillon James C. Kennedy Roy H. Pottier Joan E. Roberts |
| Affiliation: | Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA;departments of Oncology and Pathology, Queen's University, Kingston, Ontario K7L 3N6, Canada;Department of Chemistry and Chemical Engineering, The Royal Military College of Canada, Kingston, Ontario K7K 5LO, and Department of Urology, Queen's University, Kingston, Ontario K7L 3N6, Canada;Division of Science and Mathematics, Fordham University, New York, NY 10023, USA |
| Abstract: | Abstract— The experimental radioprotective agentsS–2-(3-aminopropylamino) ethyl phosphorothioate(WR–2721) and 3-amino-2-hydroxypropyl phosphorothioate(WR–77913) are also protective against photosensitized oxidation. They reduce porphyrin-induced photopolymerization of lens cytosol proteins in vitro, and phototoxic damage to mouse skin in vivo. The phototoxic dose modification factor (DMF) was 1.5 which is similar to that found in ionizing radiation. Part of the mechanism by which sulfhydryls afford this protection is by accelerating photobleaching of the porphyrins. |
| Keywords: | |