Tunable chiral monophosphines as ligands in enantioselective rhodium-catalyzed ring-opening of oxabenzonorbornadienes with amines |
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Institution: | 1. School of Pharmaceutical Sciences, Gannan Medical University, Yi Xue Yuan Road, Ganzhou, Jiangxi 341000, China;2. Institute of Creativity, Hong Kong Baptist University, Hong Kong, China;1. Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China;2. Institute of Human Virology, Sun Yat-sen University, Guangzhou 510080, PR China;1. School of Chemistry&Molecular Engineering, East China University of Science&Technology, 130 Meilong Road, Shanghai 200237, China;2. Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China;1. Delft Center for Systems and Control, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands;2. CentraleSupelec-IETR UMR 6164, Cesson-Sevigne, France |
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Abstract: | A new tunable chiral monophosphine was used as a ligand for asymmetric rhodium-catalyzed ring-opening of oxabenzonorbornadiene with amines, providing a series of chiral ring-opened products in high yields (up to 97%) and with high enantioselectivities (>99%).The reaction can be performed at rt to obtain the desired product with high enantioselectivity. |
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