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Sugar amide-pyrrolidine catalyst for the asymmetric Michael addition of ketones to nitroolefins |
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| Affiliation: | 1. Selcuk University, Department of Chemistry, 42031 Konya, Turkey;2. Giresun University, Department of Energy Systems Engineering, 28200 Giresun, Turkey;1. Departamento de Química Orgánica, Facultad de Ciencias, Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain;2. Departamento de Química Orgánica I, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastíán, Spain |
| Abstract: | New sugar amide-pyrrolidine derivatives possessing the furano form of the carbohydrate template were designed and developed as efficient and stereoselective organocatalysts for asymmetric Michael additions of ketones to nitroolefins at room temperature. Good yields and high selectivities were achieved with catalyst 2 under solvent-free and additive-free reaction conditions. |
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