Investigation of a novel diamine based chiral auxiliary in the asymmetric alkylation of ketones |
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| Institution: | 1. Department of Organic Chemistry, University of Alcala, 28871 Alcala de Henares, Madrid, Spain;2. Department of Organic Chemistry, University of Alicante, Ap. 99, 03080 Alicante, Spain |
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| Abstract: | A novel chiral auxiliary containing a pyrrolidine ring has been utilised in the preparation of various chiral ketones with good to excellent enantioselectivities (up to 92%). It has been successfully employed in aldol and Michael reactions giving moderate to high selectivity. |
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