Highly stereoselective direct aldol reactions catalyzed by a bifunctional chiral diamine |
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| Institution: | 1. Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China;2. Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University, Nanjing 211189, China;1. Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, PR China;2. Department of Chemistry and Materials, Yulin Normal University, Yulin 537000, PR China;1. Department of Organic Chemistry, Samara State Technical University, Samara 443100, Russia;2. Department of Chemistry, Moscow State University, 119991 Mosсow, Russia;1. Selcuk University, Department of Chemistry, 42031 Konya, Turkey;2. Nigde University, Ulukisla Vocational School, 51100 Nigde, Turkey;3. Giresun University, Department of Energy Systems Engineering, 28200 Giresun, Turkey |
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| Abstract: | The enantioselective organocatalytic direct aldol reactions of ketones with various aldehydes were developed by using chiral 1,2-cyclohexanediamine (DACH) based multifunctional ligands via a noncovalent catalysis mechanism. By using a catalyst, we also obtained functionalized 3-alkyl-3-hydroxyindolin-2-ones in high yields and with good to excellent enantioselectivities. |
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