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Enantioselective hydrolysis of nitriles and amides using an immobilised whole cell system |
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| Authors: | Mark A Cohen Julian S Parratt Nicholas J Turner |
| Institution: | Department of Chemistry, University of Exeter, Stocker Road, Exeter, EX4 4QD U.K. |
| Abstract: | An immobilised whole cell catalyst SP361 has been shown to hydrolyse a range of 2-alkyl arylacetonitriles 1a–3a and amides 2b, 3b with good to excellent enantioselectivity. The absolute configuration of the derived amides and/or carboxylic acids shows remarkable changes according to the structure of the nitrite substrate. |
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