Infrared spectra of thyroid tumor tissues |
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| Authors: | G B Tolstorozhev I V Skornyakov and V A Butra |
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| Institution: | (1) Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, 710038 Xi'an, PR China;(2) Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, 710032 Xi'an, PR China;(3) Department of Health Statistics, The Fourth Military Medical University, 710032 Xi'an, PR China;(4) Department of General Surgery, Xijing Hospital, The Fourth Military Medical University, 710032 Xi'an, PR China;(5) Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, 710038 Xi'an, China;(6) Traditional Chinese Medical College, 712000 Xian'yang, PR China;(7) Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University, 710032 Xi'an, PR China;(8) Department of neurosurgery, Xijing Hospital, The Fourth Military Medical University, 710032 Xi'an, PR China;(9) Department of Urology, Tangdu hospital, The Fourth Military Medical University, 710038 Xi'an, PR China |
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| Abstract: | We used infrared spectroscopy methods to study thyroid tumor tissues removed during surgery. The IR spectra of the surgical
material are compared with data from histological examination. We show that in malignant neoplasms, the spectra of proteins
in the region of C=O vibrations are different from the spectra of these substances in benign tumors and in tissues outside
the pathological focus at a distance >1 cm from the margin of the tumor. The differences in the spectra are due to changes
in the supermolecular structure of the proteins, resulting from rearrangement of the system of hydrogen bonds. We identify
the spectral signs of malignant pathologies. |
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