THE EFFECT OF ALCOHOLS WITH DIFFERENT STRUCTURES ON THE FORMATION OF WARM O/W MICROEMULSIONS |
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| Authors: | Roberta Cavalli Emilio Marengo Otto Caputo Elena Ugazio Maria Rosa Gasco |
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| Affiliation: | Dipartimento di Scienza e Tecnologia del Farmaco , Università degli Studi di Torino , Via P. Giuria 9, Torino, 10125, Italy |
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| Abstract: | The influence of twenty five different alcohols on the formation of warm oil-in-water (O/W) microemulsions was investigated. Selected concentrations of each alcohol were added to fixed amounts of stearic acid, Tween 20 and water at 65 ° C. Fifteen alcohols formed microemulsions, at least at one of the concentrations. A pattern recognition study was performed to elucidate the activities of the alcohols by Principal Component Analysis (PCA). Linear Discriminant Analysis (LDA) was used to classify them. Two classification functions, obtained for alcohols forming / not forming microemulsions, suggest that the formation of warm O/W microemulsion is linked to the nature and the dimension/lipophilicity of the alcohol. |
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