FORMATION OF MICROEMULSION AND LIQUID CRYSTAL IN BIOCOMPATIBLE SUCROSE ALKANOATE SYSTEMS |
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| Authors: | N Nakamura Y Yamaguchi B Häkansson U Olsson T Tagawa H Kunieda |
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| Institution: | 1. Graduate School of Engineering , Yokohama National University , Tokiwadai 79-5, Hodogaya-ku, Yokohama, 240-8501, Japan;2. Division of Physical Chemistry 1 , Chemical Center, University of Lund , P.O. Box 124, Lund, S, 221 00, Sweden;3. Yokohama Research Center R&4. D Division , Mitsubishi Chemical Corporation , Kamoshida-cho 1000, Aoba-ku, Yokohama, 227, Japan |
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| Abstract: | Sucrose monoalkanoates (SE) form microemulsions by mixing with lipophilic cosurfactants such as the middle-chain alcohols, or sucrose polyalkanoates. In the case that sucrose monododecanoate is combined with hexanol, a middle-phase microemulsion is produced and coexists with excess water and oil phases at optimum mixing fraction of SE and hexanol. The bicontinuous structure of the microemulsion was confirmed by means of self-diffusion coefficient on NMR measurement. A larger solubilization capability of oil is attained to a mixed mono- and poly-dodecanoate system than that of the middle-chain alcohol. It is probably due to the location of most of surfactant molecules at the micro-interface inside the microemulsion. In this system, instead of forming a three-phase region, a lamellar liquid crystal intrudes into multi-phase region since the surfactant layer is rather rigid as which was supported by the results of SAXS and ESR measurements. Further addition of a short-chain alcohol such as propanol to the mixed system leads to the flexible interface, as a consequence three-phase microemulsion with large solubilization is formed. |
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