Preparation and Evaluation of Theophylline Sustained Release Microcapsules Using Coacervation |
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| Authors: | Solmaz Ghaffari Nasim Sadri Alamdari Zahra Jafari Azar Ali Reza Dabir Siaghi Farzad Kobarfard Sanaz Ghaffari |
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| Affiliation: | 1. Department of Pharmaceutics, Pharmacy Faculty , Isfahan University of Medical Sciences , Isfahan , Iran;2. Quality Control Department , Iranian Parenteral and Pharmaceutical Co. , Tehran , Iran;3. Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences , Islamic Azad University of Tehran , Tehran , Iran;4. Young Researchers Club, Pharmacy and Pharmaceuticals Branch , Islamic Azad University of Tehran , Tehran , Iran ghafari@pharm.mui.ac.ir;6. Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences , Islamic Azad University of Tehran , Tehran , Iran;7. Department of Medical Chemistry, Faculty of Pharmacy , Shahid Beheshti University of Medical Sciences , Tehran , Iran;8. Faculty of Medicine , Qazvin University of Medical Sciences , Qazvin , Iran |
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| Abstract: | Preparation of sustained release dosage forms is one of the main objectives in drug formulation. Theophylline that has a narrow therapeutic index, making it a good choice to prepare a sustained release dosage form. Theophylline sustained release microcapsules were prepared by applying the coacervation method. The effect of the type and ratio of polymers, as well as the type of washing solvents, was studied on particle size, drug loading efficiency, and in vitro drug release profile. Results showed that Eudragit RS and RL could be more suitable polymers for preparation of sustained release microcapsules of theophylline when used in ratio of 1:1 and when the washing solvent was hexane. |
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| Keywords: | Coacervation Eudragit microcapsulation sustained release theophylline |
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