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Protein Delivery by Enteric Copolymer Nanoparticles |
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| Authors: | D Dupeyrón J Rieumont M González |
| Institution: | 1. Instituto de Materiales y Reactivos , Universidad de la Habana , Cuba;2. Facultad de Química , Universidad de la Habana , Cuba;3. Centro de Ingeniería e Investigaciones Químicas, Ciudad de la Habana , Cuba |
| Abstract: | The release profiles of bovine serum albumin nanoencapsulated into an enteric copolymer (methacrylic acid/ethyl acrylate blended with poly (ethylene glycol)) show an effective protection for this protein from the stringent pH gastric environment. The nanoParticles (nP) yield of about 90% and encapsulation efficiency of 77–78% indicate a successful control of the process. The experimental evidence leads to physical entanglements between PEG and the copolymer be considered as the driving factor to modulate the release. |
| Keywords: | Enteric copolymer PEG protein nanoencapsulation protein-matrix interaction release profile |