Copper (II)-Surfactant Complex and Its Nano Analog as Potential Antitumor Agents |
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| Authors: | Abdelftah M Badawi Nadia I Zakhary Gilane M Sabry Mohamed R Mohamed Ahmed M Mousa |
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| Institution: | 1. Applied Surfactant Laboratory, Egyptian Petroleum Research Institute , Nasr City, Cairo, Egypt;2. National Cancer Institute, Cairo University , Egypt;3. Department of Biochemistry , Faculty of Science, Ain Shams University , Cairo, Egypt |
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| Abstract: | The in vitro anticancer activity of copper cetyl trimethyl ammonium bromide (Cu-CTAB)-loaded cyclodextrin nanoparticles on Ehrlich ascites carcinoma (EAC), colon cancer cells (HCT 116), liver cancer cells (HepG-2), breast cancer cells (MCF-7), and cervix cancer cells (Hela) was investigated using MTT due assay. Cyclodextrin nanoparticles loaded with Cu-CTAB exerted in vitro anticancer activity against the previous human cancer cell lines comparable to the activity of free non-entrapped in nanoparticles macro-particle Cu-CTAB. The nano analog was synthesized by physical loading using grinding with ball mill. The ratio between Cu-CTAB and cyclodextrin oligosaccharide was 1 Cu-CTAB: 3 cyclodextrin. The particle size of the nano derivative was determined using the transmitted electron microscope (TEM). |
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| Keywords: | Antitumor agents human cancer cell lines in vitro anticancer activity nano analog surfactant complex |
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