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Chitosan-DNA Particles for DNA Delivery: Effect of Chitosan Molecular Weight on Formation and Release Characteristics |
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| Authors: | M C Morán T Laranjeira A Ribeiro M G Miguel B Lindman |
| Institution: | 1. Chemistry Department , Coimbra University , Coimbra, Portugal mcarmen@qui.uc.pt;3. Chemistry Department , Coimbra University , Coimbra, Portugal;4. Laboratory of Pharmaceutical Technology, Faculty of Pharmacy , Coimbra University , Coimbra, Portugal;5. Laboratory of Pharmaceutical Technology, Faculty of Pharmacy , Coimbra University , Coimbra, Portugal;6. Chemistry Department , Coimbra University , Coimbra, Portugal;7. Physical Chemistry 1 , Lund University , Lund, Sweden |
| Abstract: | Novel DNA-chitosan particles were prepared based on associative phase separation and interfacial diffusion. These particles formed at water/water emulsion type interfaces were characterized with respect to several properties including stability, DNA conformational state, and entrapment and release of DNA. In particular it was found that the chitosan molecular weight is a good controlling parameter. |
| Keywords: | Chitosan DNA gel particles DNA release |